Assess the Prognosis of Advanced Fibrosis due to MASH with a Simple Blood TestClinical Benefits of The Enhanced Liver Fibrosis (ELF) Test
The Enhanced Liver Fibrosis test is a non-invasive blood test that measures three direct markers of fibrosis. Direct assessment of fibrosis has proven valuable for assessing risk of progression to cirrhosis and/or liver-related events.
The most widely studied direct marker is the ELF Test which can assess active, dynamic fibrosis rather than the damage it has caused. This allows the ELF Test to be used as a prognostic marker in patients with advanced fibrosis due to MASH.
Why choose the ELF Test?
Characteristics of an Ideal Non-invasive Liver Fibrosis Test
1. Day J, et al. J Appl Lab Med. 2019 Mar; 3:815-26.
2. Parkes J, et al. Gut. 2010; 59:1245-51.
3. Irvine KM, et al. Liver Int. 2016; 36:370-7.
4. Rosenburg WM, et al. Gastroenterology. 2004; 127:1704-13
5. Nobili, et al. Gastroenterology. 2009; 136:160-7
6. Srivastava A, et al. J Hepatol. 2019; Apr 6: 50168-8278{19}30227-2. doi: 10.1016/j.hep.2019.03.033.
Clinical Benefits of ELF
A simple blood test. Any provider. Any lab.
Blood-based tests can readily support high-volume testing, do not require patient access to specialized imaging equipment or highly trained operators, and generally have lower incidence rates of failure and unreliable results reported for imaging modalities.1,2
- Access noninvasive testing with a simple blood test available to all patients, including those with type 2 diabetes mellitus and obesity.2,3
- Improve patient care by assessing risk of progression to cirrhosis and liver-related events in patients with advanced fibrosis (F3 or F4) due to MASH.4
- Enhance patient management with a blood test that facilitates more frequent prognostic assessments.
Literature Compendium
This compendium highlights the ELF Test as a prognostic tool in those with advanced fibrosis due to MASH.
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The products/features (mentioned herein) are not commercially available in all countries. Their future availability cannot be guaranteed.
*In the U.S., the ELF Test is indicated as a prognostic marker in conjunction with other laboratory findings and clinical assessments in patients with advanced fibrosis (F3 or F4) due to non-alcoholic steatohepatitis (NASH) to assess the likelihood of progression to cirrhosis and liver-related clinical events. The test is not for use in the diagnosis of NASH or for the staging of fibrosis.
References
1
Staufer K, et al. Evaluation and comparison of six noninvasive tests for prediction of significant or advanced fibrosis in nonalcoholic fatty liver disease. United European Gastroenterol J. 2019 Oct;7(8):1113-23.
2
Karlas T, et al. Evaluation of transient elastography (TE), acoustic radiation force impulse imaging (ARFI), and Enhanced Liver Function (ELF) score for detection of fibrosis in morbidly obese patients. PLoS One. 2015;10:e0141649.
3
Patel P, et al. Hepatol Commun. 2018;2:893鈥905.
4
Sanyal AJ, et al. Hepatology. 2019;70(6):1913-1927.
5
Srivastava, A. et al. Prospective evaluation of a primary care referral pathway for patients with non-alcoholic fatty liver disease. J Hepatol. 2019 Aug;71(2):371-378. doi: 10.1016/j.jhep.2019.03.033. Epub 2019 Apr 6.
6
NICE guideline NG49. National Institute of Health and Care Excellence; 2016.
7
Eddowes PJ, Sasso M, Allison M, et al. Accuracy of FibroScan Controlled Attenuation Parameter and Liver Stiffness Measurement in Assessing Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology 2019;156:1717-30.
8
Vilar-Gomez E, Chalasani N. Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers. J Hepatol 2018;68:305-15.
