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Ultrasound-derived fat fraction (UDFF) shows high accuracy in detecting hepatic steatosis

08/19/2025

A newly published meta-analysis study in demonstrated that Ultrasound-derived fat fraction (UDFF) is a highly accurate, noninvasive tool for detecting hepatic steatosis.   

The analysis synthesized data from nine independently published studies including 1,150 patients and found that UDFF achieved high sensitivity (90.40%) and specificity (83.8%) when compared to MRI – Proton Density Fat Fraction, the current non-invasive gold standard.  

These findings support UDFF as a promising, more accessible alternative to MRI, with potential advantages including lower cost and broader availability for large-scale hepatic steatosis screening.  

Siemens Healthineers is proud not only to be mentioned in this important research, but to have our imaging systems and UDFF functionality used in all but one of the nine studies analyzed. This reinforces our leadership in patient-friendly, clinically validated innovations and strengthens our commitment to advancing accessible, evidence-based imaging solutions. 
 
Read the full abstract at Spring Nature: . 

Siemens Healthineers Liver Ultrasound

Explore the clinical value of Ultrasound-derived Fat Fraction (UDFF) in liver assessment. 
See how UDFF is shaping the future of non-invasive liver diagnostics.

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