Lecture 1:
Comparative pharmacokinetics of Sirolimus and Everolimus and Latest Recommendations for their Use in TransplantationÂ
•   Learn about the mechanism of action of m-Tor inhibitors
•   Understand the differences between sirolimus and everolimus related to their current indications, different pharmacokinetics, and metabolismÂ
•   Hear a discussion around the prerequisites for therapeutic drug monitoring and their target ranges within kidney, heart and liver transplant patients, in addition to the indication in oncology for everolimus.
Speaker:
Pr. Pierre Marquet, Pharmacology-toxicology University Hospital of Limoges, France
Lecture 2:
M-Tor Inhibitors in Renal Transplantation in Clinical PracticeÂ
•   Understand how everolimus can be combined with calcineurin inhibitors (cyclosporine or tacrolimus) in kidney transplantation based on the published TRANSFORM study.Â
•   Learn about the different selected targets of immunosuppression and the diseases linked to dysregulated mTor signaling.Â
•   Hear about the comparison of the classical treatment protocol [mycophenolate (MPA) + standard dose Calcineurin Inhibitors  (sCNI)] with a new protocol [everolimus + reduced dose calcineurin  (rCNI) inhibitor].
Speaker:
Dr. Rainer Oberbauer, University Clinic Internal Medicine III / Nephrology, Austria