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BIOGRAPH OneShape the new era

Theranostics and other novel drug therapies make truly targeted treatments possible for the very first time. To realize this potential, an imaging system is needed that shortens patients’ pathways to a precise diagnosis and timely treatment.

Introducing BIOGRAPH One – the game-changing PET/MR scanner that shapes a new era for one simplified patient-centric pathway.

BIOGRAPH One – our next-generation PET/MR scanner

Benefits

siemens-healthineers_DI-MR_BIOGRAPH-One_patient_pathway

Image courtesy of University Hospital of Erlangen, Erlangen, Germany. | Study-ID: 2aaaa3604

BIOGRAPH One supports one patient-centric pathway to personalized care. By seamlessly integrating PET and MR into one comprehensive exam, it supports clinicians from diagnosis and staging, through a personalized therapy decision to regular therapy assessments to excel precision and support one streamlined approach.

BIOGRAPH One excels in PET/MR precision to support confident diagnostic decisions. Featuring the Optiso UDR Pro detector with the largest 35 cm axial FOV² and the best time resoulution² in PET/MR, it enables comprehensive capture with excellent sensitivity and ultra-fast TOF³ in real time – delivering exceptionally clear, detailed images even in low-dose settings.

Deep Resolve designed to make PET/MR exams faster than ever before

Study-ID: 2aaaa3347

With Deep Resolve for accelerated acquisition and improved resolution in 2D and 3D applications⁴, BIOGRAPH One makes PET/MR exams faster than ever before. With an exceptional 3T magnet at its heart, BIOGRAPH One delivers unparalleled performance with outstanding homogeneity, a large 55 x 55 x 50 cm³ field of view and robust gradient power.

More about Deep Resolve

BIOGRAPH One makes PET/MR patient positioning easier and more efficient so operators can spend more time on patient care. New BioMatrix Contour Coils enable operators to reduce setup times and minimize exposure to radiation. Starting the exam directly at the scanner further streamlines the workflow.

BIOGRAPH One simplifes the entire PET/MR scanning workflow with myExam Companion: an intuitive interface assisting operators with advanced automation features for PET and MR familiar planning. myExam Companion empowers operators of all experience levels with simplicity and consistency, while new acquisition modes provide a tailored scanning mode for each patient and condition.

More about myExam Companion

BIOGRAPH One reduces patient slot times by more than 50 % to under 30 minutes⁵ for standard whole-body exams, including dedicated brain protocols. With up to 5x faster positioning⁵ and 2x faster acquisition⁵ – BIOGRAPH One establishes PET/MR as a standard clinical modality, aligning patient slot times with typical clinical workflows.

siemens-healthineers_DI-MR_BIOGRAPH-One_patient_pathway

Image courtesy of University Hospital of Erlangen, Erlangen, Germany. | Study-ID: 2aaaa3604

BIOGRAPH One supports one patient-centric pathway to personalized care. By seamlessly integrating PET and MR into one comprehensive exam, it supports clinicians from diagnosis and staging, through a personalized therapy decision to regular therapy assessments to excel precision and support one streamlined approach.

Evidence

BIOGRAPH One – transform PET/MR image quality for a new era

Discover the future of personalized imaging with BIOGRAPH One, where high PET precision meets powerful MR performance. Equipped with the innovative Optiso UDR Pro PET detector and a state-of-the-art 3T magnet, this system enhances small lesion detectability and deliver great soft tissue clarity. Delivering precise quantification, ultra-fast time-of-flight³ performance, and high-quality MR imaging, BIOGRAPH One supports a more patient-centric pathway. Shape the new era in PET/MR and explore the possibilities below.

Full body imaging – BIOGRAPH One

Study-ID: 2aaaa3340 | Image courtesy of RIGS Hospital, Copenhagen, Denmark

Follow up PET/MR images show complete regression of follicular lymphoma after 15 months post immunotherapy.

75-year-old male patient, 62kg

Injected dose: 184 MBq i.v.
Uptake time: 79 min p.i.
Sequences: MRAC (VIBE-DIXON), DWI
MR TA: 5:40 min (1:25 min per bed)
PET TA: 20 min (5 min per bed)⁶
Total scan range: 110 cm (4 beds)

Brain imaging – BIOGRAPH One

Study-ID: 2aaaa3339 | Image courtesy of RIGS Hospital, Copenhagen, Denmark.

One stop shop multiparametric imaging for investigation of dementia

63-year-old male patient
Normal brain metabolism

Injected dose: 184 MBq i.v.
Uptake time: 76 min p.i.
Sequences: T1 VIBE, T1 MPRAGE, FLAIR, DWI, SWI, T2 TSE
MR TA: 12:20 min
PET TA: 24:00 min⁶

Full body imaging – BIOGRAPH One

Study-ID: 2aaaa3340 | Image courtesy of RIGS Hospital, Copenhagen, Denmark

Follow up PET/MR images show complete regression of follicular lymphoma after 15 months post immunotherapy.

75-year-old male patient, 62kg

Injected dose: 184 MBq i.v.
Uptake time: 79 min p.i.
Sequences: MRAC (VIBE-DIXON), DWI
MR TA: 5:40 min (1:25 min per bed)
PET TA: 20 min (5 min per bed)⁶
Total scan range: 110 cm (4 beds)

Full body imaging – BIOGRAPH One

Study-ID: 2aaaa3340 | Image courtesy of RIGS Hospital, Copenhagen, Denmark

Follow up PET/MR images show complete regression of follicular lymphoma after 15 months post immunotherapy.

75-year-old male patient, 62kg

Injected dose: 184 MBq i.v.
Uptake time: 79 min p.i.
Sequences: MRAC (VIBE-DIXON), DWI
MR TA: 5:40 min (1:25 min per bed)
PET TA: 20 min (5 min per bed)⁶
Total scan range: 110 cm (4 beds)

The strength of PET/MR – a quote library

Metastasized Uveal Melanoma |¹⁸F-FDG imaging | Study-ID: 2aaaa3602 | Image courtesy of University Hospital of Erlangen, Erlangen, Germany

“A clinically indicated addition of MRI to PET/CT may, depending on the body region and MRI protocol, result in a similar, or even higher overall cost than for PET/MRI, with the possible disadvantage of a prolonged time interval until treatment initiation.”

PET/MRI versus PET/CT in oncology: a prospective single-center study of 330 examinations focusing on implications for patient management and cost considerations

Marius E. Mayerhoefer et al, 2020. European Journal of Nuclear Medicine and Molecular Imaging (2020) 47:51–60.

siemens-healthineers_DI-MR_BIOGRAPH-One_prostate_cancer

Prostate cancer | Study-ID: 2aaaa3604 | Image courtesy: University Hospital of Erlangen, Erlangen, Germany

“PET/MR avoids 83% of unnecessary biopsies”

The Value of 68Ga-PSMA PET/MRI for Classifying Patients with PI-RADS 3 Lesions on Multiparametric MRI: A Prospective Single-Center Study

Jingyan Shi, et.al., J Nucl Med 2024; 65:555–559 DOI: 10.2967/jnumed.123.266742

Alzheimer’s Disease | Study-ID: 2aaaa3621 | Image courtesy of Rigshospitalet Hospital, Copenhagen, Denmark

„PET/MRI has the potential to broaden the diagnostic power and become a conventional first-line one-stop clinical imaging tool to improve our understanding of Alzheimer’s Disease.”

PET/MR Imaging: New Frontier in Alzheimer's Disease and Other Dementias

Zhang XY, Yang ZL, Lu GM, Yang GF and Zhang LJ (2017) PET/MR Imaging: New Frontier in Alzheimer's Disease and Other Dementias. Front. Mol. Neurosci. 10:343. doi: 10.3389/fnmol.2017.00343.

siemens-healthineers_DI-MR_BIOGRAPH-One_parkinsons_disease

Parkinson´s disease, ¹⁸F-FE-PE2I | Study-ID:2aaaa3709 | Image coutresy: Rigshospitalet Hospital, Copenhagen, Denmark

“PET/MR allows much better-informed quantification of disease progress or therapy effect”

PET/MR Imaging: New Frontier in Alzheimer's Disease and Other Dementias

Zhang XY, Yang ZL, Lu GM, Yang GF and Zhang LJ (2017) PET/MR Imaging: New Frontier in Alzheimer's Disease and Other Dementias. Front. Mol. Neurosci. 10:343. doi: 10.3389/fnmol.2017.00343.

Metastasized Uveal Melanoma |¹⁸F-FDG imaging | Study-ID: 2aaaa3602 | Image courtesy of University Hospital of Erlangen, Erlangen, Germany

“A clinically indicated addition of MRI to PET/CT may, depending on the body region and MRI protocol, result in a similar, or even higher overall cost than for PET/MRI, with the possible disadvantage of a prolonged time interval until treatment initiation.”

PET/MRI versus PET/CT in oncology: a prospective single-center study of 330 examinations focusing on implications for patient management and cost considerations

Marius E. Mayerhoefer et al, 2020. European Journal of Nuclear Medicine and Molecular Imaging (2020) 47:51–60.

Alzheimer’s Disease | Study-ID: 2aaaa3621 | Image courtesy of Rigshospitalet Hospital, Copenhagen, Denmark

„PET/MRI has the potential to broaden the diagnostic power and become a conventional first-line one-stop clinical imaging tool to improve our understanding of Alzheimer’s Disease.”

PET/MR Imaging: New Frontier in Alzheimer's Disease and Other Dementias

Zhang XY, Yang ZL, Lu GM, Yang GF and Zhang LJ (2017) PET/MR Imaging: New Frontier in Alzheimer's Disease and Other Dementias. Front. Mol. Neurosci. 10:343. doi: 10.3389/fnmol.2017.00343.

siemens-healthineers_DI-MR_BIOGRAPH-One_parkinsons_disease

Parkinson´s disease, ¹⁸F-FE-PE2I | Study-ID:2aaaa3709 | Image coutresy: Rigshospitalet Hospital, Copenhagen, Denmark

“PET/MR allows much better-informed quantification of disease progress or therapy effect”

PET/MR Imaging: New Frontier in Alzheimer's Disease and Other Dementias

Zhang XY, Yang ZL, Lu GM, Yang GF and Zhang LJ (2017) PET/MR Imaging: New Frontier in Alzheimer's Disease and Other Dementias. Front. Mol. Neurosci. 10:343. doi: 10.3389/fnmol.2017.00343.

Metastasized Uveal Melanoma |¹⁸F-FDG imaging | Study-ID: 2aaaa3602 | Image courtesy of University Hospital of Erlangen, Erlangen, Germany

“A clinically indicated addition of MRI to PET/CT may, depending on the body region and MRI protocol, result in a similar, or even higher overall cost than for PET/MRI, with the possible disadvantage of a prolonged time interval until treatment initiation.”

PET/MRI versus PET/CT in oncology: a prospective single-center study of 330 examinations focusing on implications for patient management and cost considerations

Marius E. Mayerhoefer et al, 2020. European Journal of Nuclear Medicine and Molecular Imaging (2020) 47:51–60.

BIOGRAPH One is equipped with

Full 3T performanceDeep Resolve

Open Recon architecture⁷

BioMatrix Technology State-of-the-art PET detector

Largest axial FOV in PET/MR²

Simplified user interface with myExam Companion Innovative WB scanning modes

Community

First customer voices

As the first hospital in the world to install and clinically investigate the next-generation BIOGRAPH One PET/MR, Rigshospitalet in Denmark has gained unparalleled insight into what this system can deliver: for clinicians, physicists, and, most importantly, for patients.

In this short series, hear directly from the team that brought this system to life. Each video highlights a unique perspective - from clinical workflows to physics innovation to patient outcomes - all centered around how BIOGRAPH One is shaping the new era in PET/MR.

PET/MR on MAGNETOM World

PET/MR Hot Topics page

Explore our PET/MR seminar series, dive into our clinical image gallery, access scientific publications, and discover cutting-edge protocols that showcase the power of PET/MR in transforming precision medicine.

Clinical Talks on PET/MR

Publications on PET/MR

A Milestone in Medical Imaging: The Pioneering Development of the First Integrated PET/MR Scanner at Siemens Healthineers

Holger Schmidt; Marc Lauterbach; Manuel Schneider; Hans Wehrl; Matthias Schmand; James Corbeil; David Faul; Silvia Dias Almeida; Matthias Fenchel

Downloads

BIOGRAPH One press release

Services

1

Acquired on BIOGRAPH mMR. Images from BIOGRAPH mMR are provided to illustrate typical PET/MR imaging capabilities and are not specific to BIOGRAPH One.

2

Compared to other PET/MR systems. Data on file.

3

Ultra-fast time of flight (TOF) is defined as less than 275 picoseconds (ps). Data on file.

4

In combination with acceleration techniques as e.g. PAT4.

5

Preliminary data based on an internal single measurement. Patient slot time is defined as time in PET/MR exam room. Data on file.

6

For testing IQ purposes.

7

Open Recon is to add clinical reconstructions to the system, if signed and released for clinical use by Siemens Healthineers. Any other image reconstruction used, e.g., by researchers, is automatically labelled not for diagnostic use, which may require observation of national regulations.