Procalcitonin (PCT) Testing and the Management of Sepsis

Sepsis is a leading cause of death in hospitals worldwide, placing a significant health and economic burden on both patients and healthcare institutions. An early and accurate diagnosis can save precious time, expense, and most importantly, lives. The Siemens Healthineers B·R·A·H·M·S Procalcitonin (PCT) Assay can aid healthcare providers in the diagnosis of sepsis.

Bar chart: Improved outcomes: BRAHMS Procalcitonin (PCT) Assay. With an Abx stewardship program and PCT testing combined, the following saw reductions compared to stewardship programs that did not include PCT. 30-day readmission by 50%; 30-day readmission for infection by 49%; Adverse antibiotic event by 50%; All-cause hospital mortality by 62%; infection-caused hospital mortality by 59%; and Hospital-acquired C. difficile infection by 64%

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What is Procalcitonin?
How to implement procalcitonin into your medical centers sepsis protocol (clinical)?
How to validate procalcitonin on your Atellica IM?
How incorporating procalcitonin into your antimicrobial stewardship program can improve readmission rates, adverse antibiotic rates, all-cause hospital mortality rates, and more.
How procalcitonin can be used in the time of COVID?

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CDC sepsis data and reports. Available from: https://www.cdc.gov/sepsis/datareports/index.html.

Kumar, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Critical Care Medicine. 2006;34(6):1589-95.

Available from: http://www.ncbi.nlm.nih.gov/pubmed/16625125.4. Broyles MR. Open Forum Infect Dis. 2017;4. DOI: 10.1093/ofid/ofx213.

4. Broyles MR. Open Forum Infect Dis. 2017;4. DOI: 10.1093/ofid/ofx213.

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